There's an Item Profitability report which would suffice but I think it's only in specific editions (Under “Project Costing” default reports).
You can tweak the Sales by Item Summary instead though & then memorise it for future re-use:
You can also click on the “Advanced” button to select All/Active/Non-Zero options for
row & column display
Depending on how your Items are set up, you can tweak this further to only show specific groups/types of Items.
Once happy with it, click on the “Memorise” button (next to “Modify ...”) & save it for next time.